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For a 2mg vial, adding 1ml of bacteriostatic water creates a concentration of 2mg/ml (2000mcg/ml)

To properly dispose of empty vials, ensure they are completely sealed to prevent any leaking

Increases local concentration while reducing systemic exposure

Chronic constipation patients have reduced EC cell density, decreased 5-HT synthesis, and significantly lowered colonic tissue 5-HT concentrations ( 3.2.2 Neuroendocrine alterations Neuroendocrine system dysregulation represents an important pathophysiological mechanism in chronic constipation and depression comorbidity, involving abnormalities in the HPA axis, hypothalamic-pituitary-thyroid (HPT) axis, and various gastrointestinal hormones (Konturek et al., 2011)

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